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Fluorescence of Phytochrome Adducts with Synthetic Locked Chromophores. Subsequent gates were based on fluorescence minus one and unstained controls. All the antibiotics failed, even after just a couple of exposures. Intracellular concentrations of mevalonate and IPP were measured by liquid chromatography mass spectrometry (LC-MS). The AMF warns the route of the problem is that its supply chain is reliant on only four manufacturers of the active pharmaceutical ingredient and there are many other antibiotics in a similar position (see Box 1).
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Analysis of the symbiotic relationship between minimal organisms and their hosts, and the genetic completeness of the thymidine synthesis pathway suggested that TS from the minimal organism Wigglesworthia glossinidia (W.